Serum neurofilament light chain and cognition decline in US elderly: A cross-sectional study.

ABSTRACT:

Objective

Early identification of cognitive impairment in neurodegenerative diseases like Alzheimer's disease (AD) is crucial. Neurofilament, a potential biomarker for neurological disorders, has gained attention. Our study aims to investigate the relationship between serum neurofilament light (sNfL) levels and cognitive function in elderly individuals in the United States.

Methods

This cross-sectional study analyzed data from participants aged 60 and above in the National Health and Nutrition Examination Survey (2013-2014). We collected sNfL levels, cognitive function tests, sociodemographic characteristics, comorbidities, and other variables. Weighted multiple linear regression models examined the relationship between ln(sNfL) and cognitive scores. Restricted cubic spline

SUBMITTER: Liu X 

PROVIDER: S-EPMC10791034 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature