Exploring the pathogenesis and key genes associated of acute myocardial infarction complicated with Alzheimer's disease.

ABSTRACT: Despite mounting evidence linking Acute Myocardial Infarction (AMI) to Alzheimer's disease (AD), the shared mechanism of these two conditions' occurrence remains unclear. This research aims to delve deeper into the molecular process of the occurrence of the two diseases. We retrieved the gene expression profiles of AD (GSE5281) and AMI (GSE66360) from the Gene Expression Omnibus database. Then, a total of 22 common differentially expressed genes (DEGs) including one downregulated gene and 21 upregulated genes were chosen for further analysis. Following the discovery of the common DEGs between AMI and AD, we performed protein-protein interaction analysis and hub gene identification analysis. Next, ten important hub genes were identified. Additionally, the key genes were identified by the le

SUBMITTER: Liu C 

PROVIDER: S-EPMC10791667 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature