Regulation of mitochondrial metabolism by autophagy supports leptin-induced cell migration.

ABSTRACT: Leptin is an adipokine secreted by adipose tissue, which promotes tumor progression by activating canonical signaling pathways such as MAPK/ERK. Recent studies have shown that leptin induces autophagy, and this process is involved in leptin-induced characteristics of malignancy. Autophagy is an intracellular degradation process associated with different hallmarks of cancer, such as cell survival, migration, and metabolic reprogramming. However, its relationship with metabolic reprogramming has not been clearly described. The purpose of this study was to determine the role of leptin-induced autophagy in cancer cell metabolism and its association with cellular proliferation and migration in breast cancer cells. We used ER⁺/PR⁺ and triple-negative breast cancer cell line

SUBMITTER: Garcia-Miranda A 

PROVIDER: S-EPMC10791685 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature