Peripheral neurotrophin levels during controlled crack/cocaine abstinence: a systematic review and meta-analysis.

ABSTRACT: Cocaine/crack abstinence periods have higher risk of relapse. Abstinence as initial part of the recovery process is affected by learning and memory changes that could preserve the addictive cycle. To further understand how the interruption of cocaine/crack consumption affects neurotrophin level we performed the present systematic review and meta-analysis following the PRISMA statement (number CRD42019121643). The search formula was conducted in PubMed, Web of Science, Embase, ScienceDirect, and Google Scholar databases. The inclusion criterion was cocaine use disorder in 18 to 60-year-old people, measuring at least one neurotrophin in blood before and after a controlled abstinence period. Studies without pre-post design were excluded. Five investigations had nine different reports, four of

SUBMITTER: Morelos-Santana E 

PROVIDER: S-EPMC10791690 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature