Machine learning slice-wise whole-lung CT emphysema score correlates with airway obstruction.

ABSTRACT:

Objectives

Quantitative CT imaging is an important emphysema biomarker, especially in smoking cohorts, but does not always correlate to radiologists' visual CT assessments. The objectives were to develop and validate a neural network-based slice-wise whole-lung emphysema score (SWES) for chest CT, to validate SWES on unseen CT data, and to compare SWES with a conventional quantitative CT method.

Materials and methods

Separate cohorts were used for algorithm development and validation. For validation, thin-slice CT stacks from 474 participants in the prospective cross-sectional Swedish CArdioPulmonary bioImage Study (SCAPIS) were included, 395 randomly selected and 79 from an emphysema cohort. Spirometry (FEV1/FVC) and radiologists' visual emphysema scores (sum-visual) obtain

SUBMITTER: Liden M 

PROVIDER: S-EPMC10791709 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature