Cortical and subcortical morphometric changes and their relation to cognitive impairment in isolated REM sleep behavior disorder.

ABSTRACT:

Objective

To date, very few studies have focused on structural changes and their association with cognitive performance in isolated REM sleep behaviour disorder (iRBD). Moreover, the results of these studies are inconclusive. This study aims to evaluate differences in the associations between brain morphology and cognitive tests in iRBD and healthy controls.

Methods

Sixty-three patients with iRBD and thirty-six controls underwent MRI with a 3 T scanner. The cognitive performance was assessed by a comprehensive neuropsychological battery. Based on performance, the iRBD group was divided into two subgroups with (iRBD-MCI) and without mild cognitive impairment (iRBD-NC). The high-resolution T1-weighted images were analysed using an automated atlas segmentation tool, voxel-based

SUBMITTER: Mala C 

PROVIDER: S-EPMC10791856 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature