Identifying epigenetic aging moderators using the epigenetic pacemaker.

ABSTRACT: Epigenetic clocks are DNA methylation-based chronological age prediction models that are commonly employed to study age-related biology. The difference between the predicted and observed age is often interpreted as a form of biological age acceleration, and many studies have measured the impact of environmental and disease-associated factors on epigenetic age. Most epigenetic clocks are fit using approaches that minimize the error between the predicted and observed chronological age, and as a result, they may not accurately model the impact of factors that moderate the relationship between the actual and epigenetic age. Here, we compare epigenetic clocks that are constructed using penalized regression methods to an evolutionary framework of epigenetic aging with the epigenetic pacemaker (E

SUBMITTER: Farrell C 

PROVIDER: S-EPMC10791860 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature