Relationship between vaginal microecology and human papillomavirus infection as well as cervical intraepithelial neoplasia in 2,147 women from Wenzhou, the southeast of China.

ABSTRACT:

Objective

The female reproductive tract is a significant microecological region, and its micro-environment can directly affect women's cervical health. This research aimed to investigate the effect of vaginal microecology on human papillomavirus (HPV) infection and cervical intraepithelial neoplasia(CIN).

Methods

A retrospective cohort study enrolling 2,147 women who underwent a colposcopic examination between August 2021 and August 2022 was conducted. The relationship between vaginal microecology and HPV infection as well as cervical lesions were assessed using the chi-square test, univariate and multivariate logistic regression analyses, and Cochran-Armitage trend test.

Results

HPV infection was linked to the imbalance of vaginal microecology [odds ratio (OR)=3.00,

SUBMITTER: Zang L 

PROVIDER: S-EPMC10791863 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature