Urinary microbiota signatures associated with different types of urinary diversion: a comparative study.

ABSTRACT:

Background

Radical cystectomy and urinary diversion (UD) are gold standards for non-metastatic muscle-invasive bladder cancer. Orthotopic neobladder (or Studer), ileal conduit (or Bricker) and cutaneous ureterostomy (CU) are mainstream UD types. Little is known about urinary microbiological changes after UD.

Methods

In this study, urine samples were collected from healthy volunteers and patients with bladder cancer who had received aforementioned UD procedures. Microbiomes of samples were analyzed using 16S ribosomal RNA gene sequencing, and microbial diversities, distributions and functions were investigated and compared across groups.

Results

Highest urine microbial richness and diversity were observed in healthy controls, followed by Studer patients, especially tho

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10791864 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature