Alterations in leukocyte DNA methylome are associated to immunosuppression in severe clinical phenotypes of septic patients.

ABSTRACT:

Introduction

Sepsis patients experience a complex interplay of host pro- and anti-inflammatory processes which compromise the clinical outcome. Despite considering the latest clinical and scientific research, our comprehension of the immunosuppressive events in septic episodes remains incomplete. Additionally, a lack of data exists regarding the role of epigenetics in modulating immunosuppression, subsequently impacting patient survival.

Methods

To advance the current understanding of the mechanisms underlying immunosuppression, in this study we explored the dynamics of DNA methylation using the Infinium Methylation EPIC v1.0 BeadChip Kit in leukocytes from patients suffering from sepsis, septic shock, and critically ill patients as controls, within the first 24 h after admi

SUBMITTER: Beltran-Garcia J 

PROVIDER: S-EPMC10791922 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature