Inverse association between type 2 diabetes and hepatocellular carcinoma in East Asian populations.

ABSTRACT:

Aims

To investigate the potential association between type 2 diabetes (T2D) and hepatocellular carcinoma (HCC) in East Asian populations using Mendelian randomization (MR) analyses.

Methods

Bidirectional Mendelian randomization (MR) studies were conducted using summary statistics from genome-wide association studies (GWAS) related to T2D and HCC. The potential effects of confounders such as chronic hepatitis B, chronic hepatitis C, body mass index, and alcohol intake frequency were corrected using a multivariate MR study. Various MR methods, including the inverse variance weighted (IVW) approach, were used to estimate the associations between T2D and HCC. Sensitivity analysis and assessment of heterogeneity were performed to ensure the robustness of the results.

Results</

SUBMITTER: Huo J 

PROVIDER: S-EPMC10791969 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature