Nucleolar protein TAAP1/<i>C22orf46</i> confers pro-survival signaling in non-small cell lung cancer.

ABSTRACT: Tumor cells subvert immune surveillance or lytic stress by harnessing inhibitory signals. Hence, bispecific antibodies have been developed to direct CTLs to the tumor site and foster immune-dependent cytotoxicity. Although applied with success, T cell-based immunotherapies are not universally effective partially because of the expression of pro-survival factors by tumor cells protecting them from apoptosis. Here, we report a CRISPR/Cas9 screen in human non-small cell lung cancer cells designed to identify genes that confer tumors with the ability to evade the cytotoxic effects of CD8⁺ T lymphocytes engaged by bispecific antibodies. We show that the gene C22orf46 facilitates pro-survival signals and that tumor cells devoid of C22orf46 expression exhibit increased su

SUBMITTER: Doring M 

PROVIDER: S-EPMC10791977 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature