Angiopoietin 1 and integrin beta 1b are vital for zebrafish brain development.

ABSTRACT:

Introduction

Angiopoietin 1 (angpt1) is essential for angiogenesis. However, its role in neurogenesis is largely undiscovered. This study aimed to identify the role of angpt1 in brain development, the mode of action of angpt1, and its prime targets in the zebrafish brain.

Methods

We investigated the effects of embryonic brain angiogenesis and neural development using qPCR, in situ hybridization, microangiography, retrograde labeling, and immunostaining in the angpt1^sa14264, itgb1b^mi371, tek^hu1667 mutant fish and transgenic overexpression of angpt1 in the zebrafish larval brains.

Results

We showed the co-localization of angpt1 with notch, delta, and nestin in t

SUBMITTER: Chen YC 

PROVIDER: S-EPMC10792015 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature