Qualitatively Different Delay-Dependent Working Memory Distortions in People With Schizophrenia and Healthy Control Participants.

ABSTRACT:

Background

Impairments in working memory (WM) have been well documented in people with schizophrenia (PSZ). However, these quantitative WM impairments can often be explained by nonspecific factors, such as impaired goal maintenance. Here, we used a spatial orientation delayed response task to explore a qualitative difference in WM dynamics between PSZ and healthy control participants (HCs). More specifically, we took advantage of the discovery that WM representations may drift either toward or away from previous trial targets (serial dependence). We tested the hypothesis that WM representations would drift toward the previous trial target in HCs but away from the previous trial target in PSZ.

Methods

We assessed serial dependence in PSZ (n = 31) and HCs (n = 25) using orient

SUBMITTER: Bansal S 

PROVIDER: S-EPMC10792108 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature