Achieving comparability in glycemic control between antidiabetic treatment strategies in pregnancy when using real world data.

ABSTRACT:

Purpose

Healthcare utilization databases often lack information on glycemic control, a key confounder when studying the safety of antidiabetic treatments, since patients with worse control are channeled to second-line agents, in particular insulin, versus first-line agents such as metformin. We evaluated whether adjustment for measured characteristics attains balance in glycemic control when comparing antidiabetic treatment strategies in pregnant women with pregestational type 2 diabetes (T2DM).

Methods

In a US insurance claims database, we identified 3360 women with T2DM pregnant between 2004 and 2015, of whom a subset of 996 had data on hemoglobin A_1c (HbA_1c ) levels. We selected insulin only as the comparator group and used propensity score (PS)-matc

SUBMITTER: Cesta CE 

PROVIDER: S-EPMC10792121 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature