Vitamin D receptor induces oxidative stress to promote esophageal squamous cell carcinoma proliferation via the p53 signaling pathway.

ABSTRACT:

Background

Esophageal squamous cell carcinoma (ESCC) is a common pathological esophageal cancer with poor prognosis. Vitamin D deficiency reportedly occurs in ESCC patients, and this is related to single nucleotide polymorphism of vitamin D receptor (VDR).

Objective

We investigated the effect of VDR on ESCC proliferation, invasion, and metastasis and its potential mechanism.

Methods

ESCC and normal tissues were collected from 20 ESCC patients. The ESCC tissue microarray contained 116 pairs of ESCC and normal tissues and 73 single ESCC tissues. VDR expression and its clinicopathological role were determined by real-time quantitative polymerase chain reaction, Western blot, and immunohistochemistry staining. sh-VDR and VDR overexpression were used to validate the effect

SUBMITTER: Shang QX 

PROVIDER: S-EPMC10792188 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature