Identification of the prognostic immune subtype in copy-number high endometrial cancer.

ABSTRACT:

Objective

The TCGA molecular subtype of endometrial cancer (EC) is widely applied, among which the copy-number high (CNH) subtype has the poorest prognosis. However, the heterogeneity of this subtype remains elusive. In this study, we aimed to identify heterogeneous immune subtypes in CNH EC and explore their prognostic significance.

Methods

We collected 60 CNH EC cases in the TCGA database and performed unsupervised cluster analysis based on the enrichment scores of immune-related gene signatures to identify immune subtypes. We described their immune characteristics and prognoses and conducted differential gene analysis and lasso regression to identify a prognostic biomarker, GZMM. For experimental validation, we performed immunohistochemical staining of GZMM in 39 p53-posi

SUBMITTER: Mao M 

PROVIDER: S-EPMC10792215 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature