Involvement of single nucleotide polymorphisms of junction adhesion molecule with small vessel vascular dementia.

ABSTRACT:

Objectives

It is now recognized that blood brain barrier (BBB) leakage occurs in cerebral small vascular disease (CSVD) and plays a significant role in the pathophysiology of vascular dementia. We hypothesized that genetic polymorphisms of junctional adhesion molecule-A (JAM-A) (which may result in compromised structure of tight junction proteins that form the BBB) in combination with cerebrovascular risk factors hypertension, lipid disorders, and type 2 diabetes may result in BBB leakage and increase the individual's risk of CSVD-related dementia.

Methods

In this case-control study, 97 controls with a mean Mini-Mental State Exam (MMSE) score of 29 and 38 CSVD-related vascular dementia participants (mean MMSE score of 19) were recruited. Bloods were collected for the analysi

SUBMITTER: Xie P 

PROVIDER: S-EPMC10792332 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature