Sex-dependent Prognosis of Patients with Advanced Soft Tissue Sarcoma.

ABSTRACT:

Purpose

To examine whether overall survival (OS) differs for male and female patients with advanced soft-tissue sarcoma (STS).

Experimental design

The study included patients from Kaiser Permanente Northern California and Stanford Cancer Center with grade 2 and 3 locally advanced or metastatic STS whose tumor underwent next-generation sequencing. We used Cox regression modeling to examine association of sex and OS adjusting for other important factors.

Results

Among 388 eligible patients, 174 had leiomyosarcoma (LMS), 136 had undifferentiated pleomorphic sarcoma (UPS), and 78 had liposarcoma. OS for male versus female patients appeared to be slightly better among the full cohort [HR = 0.89; 95% confidence interval (CI), 0.66-1.20]; this association appeared to be stro

SUBMITTER: Pan M 

PROVIDER: S-EPMC10792361 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature