Proteomics analysis of carotid body tumor revealed potential mechanisms and molecular differences among Shamblin classifications.

ABSTRACT: Carotid body tumors (CBTs) are a rare type of paraganglioma, and surgical resection is the only effective treatment. Because of the proximity of CBTs to the carotid artery, jugular vein, and cranial nerve, surgery is extremely difficult, with high risks of hemorrhage and neurovascular injury. The Shamblin classification is used for CBT clinical evaluation; however, molecular mechanisms underlying classification differences remain unclear. This study aimed to investigate pathogenic mechanisms and molecular differences between CBT types. In Shamblin I, II, and III tumors, differentially expressed proteins (DEPs) were identified using direct data-independent acquisition (DIA). DEPs were validated using immunohistochemistry. Proteomics profiling of three Shamblin subtypes differed significantl

SUBMITTER: Lv Y 

PROVIDER: S-EPMC10792421 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature