Batch vs. continuous direct compression - a comparison of material processability and final tablet quality.

ABSTRACT: In this study, an in-depth comparison was made between batch and continuous direct compression using similar compression set-ups. The overall material processability and final tablet quality were compared and evaluated. Correlations between material properties, process parameters and final tablet properties were made via multivariate data analyses. In total, 10 low-dosed (1% w/w) and 10 high-dosed (40% w/w) formulations were processed, using a total of 10 different fillers/filler combinations. The trials indicated that the impact of filler type, drug load or process settings was similar for batch and continuous direct compression. The main differentiator between batch and continuous was the flow dynamics in the operating system, where properties related to flow, compressibility and

SUBMITTER: Bekaert B 

PROVIDER: S-EPMC10792456 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature