Detection of Pancreatic Ductal Adenocarcinoma-Associated Proteins in Serum.

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancer types, partly because it is frequently identified at an advanced stage, when surgery is no longer feasible. Therefore, early detection using minimally invasive methods such as blood tests may improve outcomes. However, studies to discover molecular signatures for the early detection of PDAC using blood tests have only been marginally successful. In the current study, a quantitative glycoproteomic approach via data-independent acquisition mass spectrometry was utilized to detect glycoproteins in 29 patient-matched PDAC tissues and sera. A total of 892 N-linked glycopeptides originating from 141 glycoproteins had PDAC-associated changes beyond normal variation. We further evaluated the specificity of these serum-detecta

SUBMITTER: Lih TM 

PROVIDER: S-EPMC10792492 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature