Prenatal air pollution, maternal immune activation, and autism spectrum disorder.

ABSTRACT:

Background

Autism Spectrum Disorder (ASD) risk is highly heritable, with potential additional non-genetic factors, such as prenatal exposure to ambient particulate matter with aerodynamic diameter < 2.5 µm (PM_2.5) and maternal immune activation (MIA) conditions. Because these exposures may share common biological effect pathways, we hypothesized that synergistic associations of prenatal air pollution and MIA-related conditions would increase ASD risk in children.

Objectives

This study examined interactions between MIA-related conditions and prenatal PM_2.5 or major PM_2.5 components on ASD risk.

Methods

In a population-based pregnancy cohort of children born between 2001 and 2014 in Southern California, 318,751 mother-child pairs were fo

SUBMITTER: Yu X 

PROVIDER: S-EPMC10792527 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature