Psilocybin acutely alters the functional connectivity of the claustrum with brain networks that support perception, memory, and attention.

ABSTRACT: Psychedelic drugs, including the serotonin 2a (5-HT_2A) receptor partial agonist psilocybin, are receiving renewed attention for their possible efficacy in treating a variety of neuropsychiatric disorders. Psilocybin induces widespread dysregulation of cortical activity, but circuit-level mechanisms underlying this effect are unclear. The claustrum is a subcortical nucleus that highly expresses 5-HT_2A receptors and provides glutamatergic inputs to arguably all areas of the cerebral cortex. We therefore tested the hypothesis that psilocybin modulates claustrum function in humans. Fifteen healthy participants (10M, 5F) completed this within-subjects study in which whole-brain resting-state blood-oxygenation level-dependent (BOLD) signal was measured 100 ​min after blinde

SUBMITTER: Barrett FS 

PROVIDER: S-EPMC10792549 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature