Toxoplasma gondii infection and brain inflammation: A two-sample mendelian randomization analysis.

ABSTRACT:

Background

Toxoplasma gondii is an opportunistic parasitic protozoan that can cause highly fatal toxoplasmic encephalitis when the host immune system is compromised. However, the transition from chronic to acute infection remains poorly understood. In this study, we conducted a 180-day observation of tissue damage and inflammation in the brains of mice infected with T. gondii. Subsequently, we investigated the inflammatory factors that T. gondii infection may alter using two-sample Mendelian randomization (MR) analysis.

Methods

We first established a mouse model of T. gondii infection. Subsequently, the mice were euthanized, the brain tissue collected, and immunohistochemistry and hematoxylin and eosin staining performed to observe tissue damage a

SUBMITTER: Yao Y 

PROVIDER: S-EPMC10792577 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature