Neurobiological Clusters Are Associated With Trajectories of Overall Psychopathology in Youth.

ABSTRACT:

Background

Integrating multiple neuroimaging modalities to identify clusters of individuals and then associating these clusters with psychopathology is a promising approach for understanding neurobiological mechanisms that underlie psychopathology and the extent to which these features are associated with clinical symptoms.

Methods

We leveraged neuroimaging data from T1-weighted, diffusion-weighted, and resting-state functional magnetic resonance images from the Adolescent Brain Cognitive Development (ABCD) Study (N = 8035) and used similarity network fusion and spectral clustering to identify subgroups of participants. We examined neuroimaging measures as a function of clustering profiles using 1, 2, or 3 imaging modalities (i.e., data combinations), calculated the stabilit

SUBMITTER: Wang C 

PROVIDER: S-EPMC10792597 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature