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Increasing the versatility of the biphenyl-fused-dioxacyclodecyne class of strained alkynes.

ABSTRACT: Biphenyl-fused-dioxacyclodecynes are a promising class of strained alkyne for use in Cu-free 'click' reactions. In this paper, a series of functionalised derivatives of this class of reagent, containing fluorescent groups, are described. Studies aimed at understanding and increasing the reactivity of the alkynes are also presented, together with an investigation of the bioconjugation of the reagents with an azide-labelled protein.

SUBMITTER: Forshaw S

PROVIDER: S-EPMC10792613 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Increasing the versatility of the biphenyl-fused-dioxacyclodecyne class of strained alkynes.

Forshaw Sam S Parker Jeremy S JS Scott William T WT Knighton Richard C RC Tiwari Neelam N Oladeji Samson M SM Stevens Andrew C AC Chew Yean Ming YM Reber Jami J Clarkson Guy J GJ Balasubramanian Mohan K MK Wills Martin M

Organic & biomolecular chemistry 20240117 3

Biphenyl-fused-dioxacyclodecynes are a promising class of strained alkyne for use in Cu-free 'click' reactions. In this paper, a series of functionalised derivatives of this class of reagent, containing fluorescent groups, are described. Studies aimed at understanding and increasing the reactivity of the alkynes are also presented, together with an investigation of the bioconjugation of the reagents with an azide-labelled protein. ...[more]

PMID: 38131271

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