ISanXoT: A standalone application for the integrative analysis of mass spectrometry-based quantitative proteomics data.

ABSTRACT: Many bioinformatics tools are available for the quantitative analysis of proteomics experiments. Most of these tools use a dedicated statistical model to derive absolute quantitative protein values from mass spectrometry (MS) data. Here, we present iSanXoT, a standalone application that processes relative abundances between MS signals and then integrates them sequentially to upper levels using the previously published Generic Integration Algorithm (GIA). iSanXoT offers unique capabilities that complement conventional quantitative software applications, including statistical weighting and independent modeling of error distributions in each integration, aggregation of technical or biological replicates, quantification of posttranslational modifications, and analysis of coordinated protein be

SUBMITTER: Rodriguez JM 

PROVIDER: S-EPMC10792623 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature