Immune checkpoint CD161/LLT1-associated immunological landscape and diagnostic value in oral squamous cell carcinoma.

ABSTRACT: An active host adaptive response is characterized by the existence of programmed cell death protein 1 (PD-1)⁺ /IFN-γ⁺ cytotoxic T cells and IFN-γ-induced PD-L1⁺ tumor cells (TCs), which predicts high response rate to anti-PD-1/L1 therapy. Recently, CD161 and its ligand LLT1 (CLEC2D) have been identified as an emerging checkpoint for immunotherapy. Clarifying its heterogeneous clinical expression pattern and its immune landscape is a prerequisite for maximizing the response rate of CD161 blockade therapy in a specific population of oral squamous cell carcinoma (OSCC) patients. Here, we investigated the expression pattern of CD161/LLT1 and its association with major immunocytes (T cells, B cells, NK cells, and macrophages) by multiplex immunofluorescence, imm

SUBMITTER: Hu X 

PROVIDER: S-EPMC10792702 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature