Impact of disrupted cyclic stretch in intracranial aneurysms: Insights from endothelial cell transcriptomic dataset.

ABSTRACT: Intracranial aneurysm (IA) rupture is a common cause of hemorrhagic stroke. The treatment of unruptured IAs is a challenging decision that requires delicate risk stratification. The rate of poor clinical outcomes after surgical intervention (aneurysm clipping) or endovascular coiling remains elevated (6.7% and 4.8%, respectively), and they do not provide an absolute guarantee to prevent IA growth and rupture. Currently, there is no pharmaceutical treatment to cure or stabilize IAs. Improving the current or developing new treatments for IA disease would require a better understanding of the cellular and molecular mechanisms occurring in the different stages of the disease. Hemodynamic forces play a critical role in IA disease. While the role of wall shear stress in IAs is well-established,

SUBMITTER: Diagbouga MR 

PROVIDER: S-EPMC10792734 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature