Circulating acetylcholine serves as a potential biomarker role in pulmonary hypertension.

ABSTRACT:

Background

An increased acetylcholine (ACh) level in the right ventricle tissue of pulmonary hypertension (PH) was revealed, which indicated the important role of ACh in disease pathogenesis. However, the relationship between plasma ACh levels and disease conditions and patients' prognosis has not been investigated. We aimed to explore the association between plasma ACh levels and the prognosis of patients with PH. We also discussed the feasibility of plasma ACh as a biomarker, which may contribute to the management of PH patients in the future.

Methods

Patients with confirmed PH in Fuwai Hospital from April 2019 to August 2020 were enrolled. The primary clinical outcome in this study was defined as a composite outcome, including death/lung transplantation, heart failure, an

SUBMITTER: Yang Y 

PROVIDER: S-EPMC10792774 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature