Splenic monocytes drive pathogenic subretinal inflammation in age-related macular degeneration.

ABSTRACT: Age-related macular degeneration (AMD) is invariably associated with the chronic accumulation of activated mononuclear phagocytes in the subretinal space. The mononuclear phagocytes are composed of microglial cells but also of monocyte-derived cells, which promote photoreceptor degeneration and choroidal neovascularization. Infiltrating blood monocytes can originate directly from bone marrow, but also from a splenic reservoir, where bone marrow monocytes develop into angiotensin II receptor (ATR1)⁺ splenic monocytes. The involvement of splenic monocytes in neurodegenerative diseases such as AMD is not well understood. Using acute inflammatory and well-phenotyped AMD models, we demonstrate that angiotensin II mobilizes ATR1⁺ splenic monocytes, which we show are defined

SUBMITTER: Roubeix C 

PROVIDER: S-EPMC10792815 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature