Monkeypox virus-associated meningoencephalitis diagnosed by detection of intrathecal antibody production.

ABSTRACT:

Background

In the 2022 mpox-outbreak most patients presented with mild symptoms. Central nervous system (CNS) involvement has previously been described as a rare and severe complication of mpox; however, diagnostic findings in cerebrospinal fluid (CSF) analysis and neuroimaging studies have only been reported in one case previously.

Case presentation

We report a previously healthy 37-year-old man with mpox complicated by encephalitis. He first presented with painful skin lesions and genital ulcers; polymerase chain reaction (PCR) from the lesions was positive for mpox. Twelve days later he was admitted with fever and confusion. Neuroimaging and CSF analysis indicated encephalitis. The CSF was PCR-negative for monkeypox virus but intrathecal antibody production was detected.

SUBMITTER: Karin H 

PROVIDER: S-EPMC10792818 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature