Dataset Information

Can instrumentation kinematics affect postoperative pain and substance P levels? A randomized controlled trial.

ABSTRACT:

Background

This study aimed to assess the influence of continuous rotation and reciprocation kinematics on postoperative pain (POP) levels and substance P (SP) levels in patients diagnosed with irreversible pulpitis and symptomatic apical periodontitis (SAP).

Materials and subjects

A total of twenty patients were randomly assigned into two groups: Continuous Rotation Group (CRG) (n = 10), subjected to mechanical preparation with the EdgeEndox7 rotary system (Albuquerque, NM, USA), and Reciprocation Group (RG) (n = 10), treated with the EdgeOne Fire reciprocating system (Albuquerque, NM, USA). Apical fluid (AF) samples were collected, and SP levels were quantified through radioimmunoassay. POP was assessed using the Numerical Rating Scale (NRS) at various time intervals (preoperatively, 6 h, 12 h, 24 h, 48 h, and 72 h). Data were statistically analyzed utilizing the independent t-test, Mann-Whitney U test, Friedman's test, and Nemenyi post hoc test.

Results

There was a significant increase in SP levels in the reciprocating group compared to the continuous rotation group (P ≤ 0.05). Additionally, patients in the reciprocating group reported significantly higher POP levels (P ≤ 0.05) at all measured intervals (6 h, 12 h, 24 h, and 48 h), with both groups exhibiting similar pain level reductions at the 72-hour mark.

Conclusion

Our findings suggest that continuous rotation kinematics in root canal preparation leads to a considerable reduction in SP expression and POP.

Trial registration

The study protocol was retrospectively registered on the www.

Clinicaltrials

gov database (NCT06081335) at (13/10/2023) after the approval of the Ethics Committee, Faculty of Dentistry, Ain Shams University (FDASU-RecIM012135).

SUBMITTER: Abdel-Baset ST

PROVIDER: S-EPMC10792914 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Publications

Can instrumentation kinematics affect postoperative pain and substance P levels? A randomized controlled trial.

Abdel-Baset Salma Talaat ST Fahmy Sarah Hossam SH Obeid Maram Farouk MF

BMC oral health 20240117 1

<h4>Background</h4>This study aimed to assess the influence of continuous rotation and reciprocation kinematics on postoperative pain (POP) levels and substance P (SP) levels in patients diagnosed with irreversible pulpitis and symptomatic apical periodontitis (SAP).<h4>Materials and subjects</h4>A total of twenty patients were randomly assigned into two groups: Continuous Rotation Group (CRG) (n = 10), subjected to mechanical preparation with the EdgeEndox7 rotary system (Albuquerque, NM, USA), ...[more]

PMID: 38233887

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Dataset Information

Can instrumentation kinematics affect postoperative pain and substance P levels? A randomized controlled trial.

Background

Materials and subjects

Results

Conclusion

Trial registration

Clinicaltrials

Publications

Can instrumentation kinematics affect postoperative pain and substance P levels? A randomized controlled trial.

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