Loss of cardiac mitochondrial complex I persulfidation impairs NAD⁺ homeostasis in aging.

ABSTRACT: Protein persulfidation is a significant post-translational modification that involves addition of a sulfur atom to the cysteine thiol group and is facilitated by sulfide species. Persulfidation targets reactive cysteine residues within proteins, influencing their structure and/or function across various biological systems. This modification is evolutionarily conserved and plays a crucial role in preventing irreversible cysteine overoxidation, a process that becomes prominent with aging. While, persulfidation decreases with age, its levels in the aged heart and the functional implications of such a reduction in cardiac metabolism remain unknown. Here we interrogated the cardiac persulfydome in wild-type adult mice and age-matched mice lacking the two sulfide generating enzymes, namely cysta

SUBMITTER: Drekolia MK 

PROVIDER: S-EPMC10792955 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature