Itaconate and citrate releasing polymer attenuates foreign body response in biofabricated cardiac patches.

ABSTRACT: Application of cardiac patches to the heart surface can be undertaken to provide support and facilitate regeneration of the damaged cardiac tissue following ischemic injury. Biomaterial composition is an important consideration in the design of cardiac patch materials as it governs host response to ultimately prevent the undesirable fibrotic response. Here, we investigate a novel patch material, poly (itaconate-co-citrate-co-octanediol) (PICO), in the context of cardiac implantation. Citric acid (CA) and itaconic acid (ITA), the molecular components of PICO, provided a level of protection for cardiac cells during ischemic reperfusion injury in vitro. Biofabricated PICO patches were shown to degrade in accelerated and hydrolytic conditions, with CA and ITA being release

SUBMITTER: Bannerman D 

PROVIDER: S-EPMC10792972 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature