Bioactive VS₄-based sonosensitizer for robust chemodynamic, sonodynamic and osteogenic therapy of infected bone defects.

ABSTRACT:

Background

Most bone defects caused by bone disease or trauma are accompanied by infection, and there is a high risk of infection spread and defect expansion. Traditional clinical treatment plans often fail due to issues like antibiotic resistance and non-union of bones. Therefore, the treatment of infected bone defects requires a strategy that simultaneously achieves high antibacterial efficiency and promotes bone regeneration.

Results

In this study, an ultrasound responsive vanadium tetrasulfide-loaded MXene (VSM) Schottky junction is constructed for rapid methicillin-resistant staphylococcus aureus (MRSA) clearance and bone regeneration. Due to the peroxidase (POD)-like activity of VS₄ and the abundant Schottky junctions, VSM has high electron-hole separation e

SUBMITTER: He Y 

PROVIDER: S-EPMC10792985 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature