Impaired visual-motor functional connectivity in first-episode medication-naive patients with major depressive disorder.

ABSTRACT: The perceptual dysfunctions have been fundamental causes of cognitive and emotional problems in patients with major depressive disorder. However, visual system impairment in depression has been underexplored. Here, we explored functional connectivity in a large cohort of first-episode medication-naïve patients with major depressive disorder (n = 190) and compared it with age- and sex-matched healthy controls (n = 190). A recently developed individual-oriented approach was applied to parcellate the cerebral cortex into 92 regions of interest using resting-state functional magnetic resonance imaging data. Significant reductions in functional connectivities were observed between the right lateral occipitotemporal junction within the visual network and 2 regions of interest within the sensorim

SUBMITTER: Hu Y 

PROVIDER: S-EPMC10793073 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature