Self-assembled and perfusable microvasculature-on-chip for modeling leukocyte trafficking.

ABSTRACT: Leukocyte recruitment from blood to tissue is a process that occurs at the level of capillary vessels during both physiological and pathological conditions. This process is also relevant for evaluating novel adoptive cell therapies, in which the trafficking of therapeutic cells such as chimeric antigen receptor (CAR)-T cells throughout the capillaries of solid tumors is important. Local variations in blood flow, mural cell concentration, and tissue stiffness contribute to the regulation of capillary vascular permeability and leukocyte trafficking throughout the capillary microvasculature. We developed a platform to mimic a biologically functional human arteriole-venule microcirculation system consisting of pericytes (PCs) and arterial and venous primary endothelial cells (ECs) embedded wit

SUBMITTER: Hirth E 

PROVIDER: S-EPMC10793075 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature