Magnetoelectric Nanodiscs Enable Wireless Transgene-Free Neuromodulation.

ABSTRACT: Deep-brain stimulation (DBS) with implanted electrodes revolutionized treatment of movement disorders and empowered neuroscience studies. Identifying less invasive alternatives to DBS may further extend its clinical and research applications. Nanomaterial-mediated transduction of magnetic fields into electric potentials offers an alternative to invasive DBS. Here, we synthesize magnetoelectric nanodiscs (MENDs) with a core-double shell Fe₃O₄-CoFe₂O₄-BaTiO₃ architecture with efficient magnetoelectric coupling. We find robust responses to magnetic field stimulation in neurons decorated with MENDs at a density of 1 μg/mm² despite individual-particle potentials below the neuronal excitation threshold. We propose a model for repe

SUBMITTER: Kim YJ 

PROVIDER: S-EPMC10793401 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature