Cell-Specific Gene Networks and Drivers in Rheumatoid Arthritis Synovial Tissues.

ABSTRACT: Rheumatoid arthritis (RA) is a common autoimmune and inflammatory disease characterized by inflammation and hyperplasia of the synovial tissues. RA pathogenesis involves multiple cell types, genes, transcription factors (TFs) and networks. Yet, little is known about the TFs, and key drivers and networks regulating cell function and disease at the synovial tissue level, which is the site of disease. In the present study, we used available RNA-seq databases generated from synovial tissues and developed a novel approach to elucidate cell type-specific regulatory networks on synovial tissue genes in RA. We leverage established computational methodologies to infer sample-specific gene regulatory networks and applied statistical methods to compare network properties across phenotypic groups (RA

SUBMITTER: Pelissier A 

PROVIDER: S-EPMC10793435 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature