Effects of multiple anesthetic exposures on rhesus macaque brain development: a longitudinal structural MRI analysis.

ABSTRACT: Concerns about the potential neurotoxic effects of anesthetics on developing brain exist. When making clinical decisions, the timing and dosage of anesthetic exposure are critical factors to consider due to their associated risks. In our study, we investigated the impact of repeated anesthetic exposures on the brain development trajectory of a cohort of rhesus monkeys (n = 26) over their first 2 yr of life, utilizing longitudinal magnetic resonance imaging data. We hypothesized that early or high-dose anesthesia exposure could negatively influence structural brain development. By employing the generalized additive mixed model, we traced the longitudinal trajectories of brain volume, cortical thickness, and white matter integrity. The interaction analysis revealed that age and cumulative an

SUBMITTER: Kim J 

PROVIDER: S-EPMC10793576 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature