Catalytic acceptorless dehydrogenative borylation of styrenes enabled by a molecularly defined manganese complex.

ABSTRACT: In this study, we employed a 3d metal complex as a catalyst to synthesize alkenyl boronate esters through the dehydrogenative coupling of styrenes and pinacolborane. The process generates hydrogen gas as the sole byproduct without requiring an acceptor, rendering it environmentally friendly and atom-efficient. This methodology demonstrated exceptional selectivity for dehydrogenative borylation over direct hydroboration. Additionally, it exhibited a preference for borylating aromatic alkenes over aliphatic ones. Notably, derivatives of natural products and bioactive molecules successfully underwent diversification using this approach. The alkenyl boronate esters served as precursors for the synthesis of various pharmaceuticals and potential anticancer agents. Our research involved comprehen

SUBMITTER: Das K 

PROVIDER: S-EPMC10793603 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature