COT-TT vaccine attenuates cocaine-seeking and cocaine-conditioned place preference in rats.

ABSTRACT: Vaccination active, promising alternative immunological strategy to treat of CUD. Various models of cocaine vaccines have been evaluated in animals and humans with relative success. In this sense, it is necessary to improve or optimize the cocaine vaccines already evaluated. Our laboratory previously reported the efficacy of the tetanus toxoid-conjugated morphine vaccine (M₆-TT). The M₆-TT vaccine can generate high titers of antibodies and reduce heroin-induced behavioral effects in rodents. So, it would be plausible to assume that if we modify the M₆-TT vaccine by changing the hapten and maintaining the rest of the structural elements of the vaccine, we will maintain the properties of the M₆-TT vaccine (high antibody titers). The objective of th

SUBMITTER: Barbosa-Mendez S 

PROVIDER: S-EPMC10793666 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature