Animal and plant protein intake during infancy and childhood DNA methylation: a meta-analysis in the NutriPROGRAM consortium.

ABSTRACT:

Background

Higher early-life animal protein intake is associated with a higher childhood obesity risk compared to plant protein intake. Differential DNA methylation may represent an underlying mechanism.

Methods

We analysed associations of infant animal and plant protein intakes with DNA methylation in early (2-6 years, N = 579) and late (7̄-12 years, N = 604) childhood in two studies. Study-specific robust linear regression models adjusted for relevant confounders were run, and then meta-analysed using a fixed-effects model. We also performed sex-stratified meta-analyses. Follow-up analyses included pathway analysis and eQTM look-up.

Results

Infant animal protein intake was not associated with DNA methylation in early childhood, but was associated with

SUBMITTER: El Sharkawy M 

PROVIDER: S-EPMC10793674 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature