Age-Dependent Regulation of Dendritic Spine Density and Protein Expression in Mir324 KO Mice.

ABSTRACT: Dendritic spines are small, dynamic protrusions along the dendrite that comprise more than 90% of excitatory connections in the brain, making them essential sites for neuronal communication. These synaptic sites change throughout the process of development, reducing in density and shifting morphology as synapses are refined. One important class of dendritic spine regulators is microRNA (miRNA), small-noncoding RNAs that post-transcriptionally regulate gene expression. Several studies suggest that miRNA-324-5p regulates dendritic spine formation. In addition, we have previously shown that miR-324-5p plays a role in seizure and long-term potentiation, both of which involve dendritic spine changes. In this study, we aimed to characterize the role of miRNA-324-5p in developmental spine regulat

SUBMITTER: Parkins EV 

PROVIDER: S-EPMC10793736 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature