Resuscitation With Vitamin C, Hydrocortisone, and Thiamin in Children With Septic Shock: A Multicenter Randomized Pilot Study.

ABSTRACT:

Objectives

Adjunctive therapy with vitamin C, hydrocortisone, and thiamin has been evaluated in adults, but randomized controlled trial (RCT) data in children are lacking. We aimed to test the feasibility of vitamin C, hydrocortisone, and thiamin in PICU patients with septic shock; and to explore whether the intervention is associated with increased survival free of organ dysfunction.

Design

Open-label parallel, pilot RCT multicenter study. The primary endpoint was feasibility. Clinical endpoints included survival free of organ dysfunction censored at 28 days and nine secondary outcomes, shock reversal, and two proxy measures of intervention efficacy.

Setting

Six PICUs in Australia and New Zealand.

Patients

Children of age between 28 days and 18 years requiring

SUBMITTER: Schlapbach LJ 

PROVIDER: S-EPMC10793796 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature