Improved intraoperative identification of close margins in oral squamous cell carcinoma resections using a dual aperture fluorescence ratio approach: first in-human results.

ABSTRACT:

Significance

Surgical excision is the main treatment for solid tumors in oral squamous cell carcinomas, where wide local excision (achieving a healthy tissue margin of >5  mm around the excised tumor) is the goal as it results in reduced local recurrence rates and improved overall survival.

Aim

No clinical methods are available to assess the complete surgical margin intraoperatively while the patient is still on the operating table; and while recent intraoperative back-bench fluorescence-guided surgery approaches have shown promise for detecting "positive" inadequate margins (<1  mm), they have had limited success in the detection of "close" inadequate margins (1 to 5 mm). Here, a dual aperture fluorescence ratio (dAFR) approach was evaluated as a means of improving detectio

SUBMITTER: Rounds CC 

PROVIDER: S-EPMC10793906 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature