Causal associations between liver enzymes and diabetic microvascular complications: A univariable and multivariable Mendelian randomization.

ABSTRACT:

Background

Observational studies show that liver enzymes are diabetes risk factors. However, previous observational investigations on the relationship between liver enzymes and diabetic microvascular complications produced contradictory results. The purpose of this research is to examine the independent causal effects of liver enzymes on diabetic microvascular complications.

Methods

Univariable Mendelian randomization (UVMR) and multivariable Mendelian randomization (MVMR) were utilized to disentangle the causal effects. The genome-wide association study (GWAS) summary-level statistics were collected from the UK biobank and the FinnGen consortium. Single nucleotide polymorphisms (SNPs) were selected as genetic instruments with genome-wide significance (p < 5 ×10-8). Five UVM

SUBMITTER: Li Y 

PROVIDER: S-EPMC10793938 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature