Genetic susceptibility modifies the association of long-term air pollution exposure on Parkinson's disease.

ABSTRACT: Inconsistent findings exist regarding the potential association between polluted air and Parkinson's disease (PD), with unclear insights into the role of inherited sensitivity. This study sought to explore the potential link between various air pollutants and PD risk, investigating whether genetic susceptibility modulates these associations. The population-based study involved 312,009 initially PD-free participants with complete genotyping data. Annual mean concentrations of PM_2.5, PM₁₀, NO₂, and NO_x were estimated, and a polygenic risk score (PRS) was computed to assess individual genetic risks for PD. Cox proportional risk models were employed to calculate hazard ratios (HR) and 95% confidence intervals (CI) for the associations between ambient

SUBMITTER: Huang YM 

PROVIDER: S-EPMC10794179 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature